基础兽医学系

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  • 陈巍教授
  • 性别:女
  • 职称:教授
  • 硕导/博导:博导
  • 学科专业:基础兽医学
  • 最高学位:博士
  • 研究方向:天然免疫识别与调控;畜禽肠道共生菌
  • 最高学历:研究生
  • 邮箱:chw_cc@jlu.edu.cn

讲授课程

本科生:动物生理学,动物机能学实验技术

硕士生:动物生理学前沿,动物机能学实验技术

教育经历

1989.9-1994.6白求恩医科大学,医学学士

1999.9-2003.6解放军军需大学,农学硕士

2012.9-2019.6威廉希尔williamhill,农学博士

工作经历

1994.7-2004.7解放军军需大学训练部,馆员

2004.8-2005.12中科院文献情报中心,馆员

2006.8-2009.5加拿大戴尔豪斯大学微生物与免疫学系,访问学者

2010.1-2010.8william威廉亚洲,讲师

2010.9-2021.8william威廉亚洲,副教授

2021.9-william威廉亚洲,教授

科研项目

1.鸡肠道类芽孢杆菌属新种YPG26产新型细菌素抑制产气荚膜梭菌定植的研究(项目批准号:32070119),国家自然科学基金面上项目,58万元,2021.01-2024.12,主持

2.IFI204促进NETs形成以限制金葡菌增殖的研究(项目批准号:31872457),国家自然科学基金面上项目,59万元,2019.01-2022.12,主持

3.沙门菌黏膜感染中核酸识别受体IFI16的调控作用及机制研究(JJKH20170819KJ),吉林省教育厅科学技术研究“十三五”规划课题,3万元,2017.01-2018.12,主持

4.P204信号与金葡菌相互调控的分子机制研究(20160101232JC),吉林省科技厅科技发展计划,10万元,2016.01-2018.12,主要参与人

5.HBV融合蛋白表达与纯化(3R2153446201),横向课题,10万元,2015.01-2017.12,主持

6.沙门氏菌感染过程中AIM2的免疫调控作用及其机制研究(项目批准号:31372410),国家自然科学基金面上项目,80万元,2014.01-2017.12,主要参与人

学术论文

1.Yu Gao#, Jian-Gang Zhang#, Zhen-Zhen Liu, Ke Ma, Xiao-Qi Lin, Jia-Bao Zhang,Wei Chen*, YongJun Yang*. Extracellular trap can be trained as a memory response.Virulence. 2022, 13(1):471-482

2.Zhen-Zhen Liu#,Wei Chen#, Cheng-Kai Zhou, Ke Ma, Yu Gao, Yong-Jun Yang*. Stimulator of Interferon Genes (STING) Promotes Staphylococcus aureus-Induced Extracellular Traps Formation via the ROS-ERK Signaling Pathway. Front Cell Dev Biol. 2022, 10:836880

3.Ke Ma#,Wei Chen#, Shi-Qing Yan, Zhen-Zhen Liu, Xiao-Qi Lin, Jia-Bao Zhang, Yu Gao, Tao Wang, Jian-Gang Zhang, Yong-Jun Yang*. Purification, Characterization, Mode of Action, and Application of Jileicin, a Novel Antimicrobial from Paenibacillus jilinensis YPG26. J Agric Food Chem. 2022, 70(18):5570-5578

4.Ke Ma#,Wei Chen#, Shi‑Qing Yan, Xiao‑Qi Lin, Zhen‑Zhen Liu, Jia‑Bao Zhang, Yu Gao, Yong‑Jun Yang*. Genome mining reveals polysaccharide-degrading potential and new antimicrobial gene clusters of novel intestinal bacterium Paenibacillus jilinensis sp. nov. BMC Genomics, 2022, 23:380

5.Zhen-Zhen Liu#, Yong-Jun Yang#, Feng-Hua Zhou, Ke Ma, Xiao-Qi Lin, Shi-Qing Yan, Yu Gao,Wei Chen*. GSDMD contributes to host defence against Staphylococcus aureus skin infection by suppressing the Cxcl1–Cxcr2 axis. Veterinary Research, 2021 May 19;52(1):71

6.Zhen-Zhen Liu#, Yong-Jun Yang#, Cheng-Kai Zhou, Shi-Qing Yan, Ke Ma, Yu Gao andWei Chen*.STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis. Front. Immunol., 2021 May 31;12:636861

7.Hu GQ#,Yang YJ#,Qin XX,Qi S,Zhang J,Yu SX,Du CT,Chen W*. SalmonellaOuter Protein B Suppresses Colitis Development via Protecting Cell From Necroptosis.Front Cell Infect Microbiol.2019 Apr 9;9:87

8.Chen W#,Yu SX#,Zhou FH,Zhang XJ,Gao WY,Li KY,Liu ZZ,Han WY*,Yang YJ*. DNASensorIFI204Contributes to Host Defense AgainstStaphylococcus aureusInfection in Mice.Front Immunol.2019 Mar 18;10:474

9.Zhang J#,Qin D#,Yang YJ#,Hu GQ,Qin XX,Du CT,Chen W*. MLKLdeficiency inhibits DSS-induced colitis independent of intestinal microbiota.Mol Immunol.2019 Mar;107:132-141

10.Yu SX#,Chen W#,Liu ZZ,Zhou FH,Yan SQ,Hu GQ,Qin XX,Zhang J,Ma K,Du CT,Gu JM,Deng XM,Han WY,Yang YJ*. Non-Hematopoietic MLKL Protects AgainstSalmonellaMucosal Infection by Enhancing Inflammasome Activation.Front Immunol.2018 Feb 2;9:119

11.Yu SX#,Zhou FH#,Chen W#,Jiang GM,Du CT,Hu GQ,Liu ZZ,Yan SQ,Gu JM,Deng XM,Lin TJ,Duan EK,Yang YJ*. Decidual Stromal Cell Necroptosis Contributes to Polyinosinic-Polycytidylic Acid-Triggered Abnormal Murine Pregnancy.Front Immunol.2017 Aug 2;8:916

12.Yu SX#,Chen W#,Hu XZ,Feng SY,Li KY,Qi S,Lei QQ,Hu GQ,Li N,Zhou FH,Ma CY,Du CT,Yang YJ*. Liver X receptors agonists suppress NLRP3 inflammasome activation.Cytokine.2017 Mar;91:30-37

13.Lv H#,Zhu C#,Liao Y,Gao Y,Lu G,Zhong W,Zheng Y,Chen W*,Ci X*. Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways.Respir Physiol Neurobiol.2015 Sep 15;216:43-51

14.Chu X#,Chen W#,Li N,Hu XZ,Du CT,Yu SX,Zhou M,Zhang XJ,Jiang GM,Han WY,Deng XM,Yang YJ*. Cytosolic double-stranded DNA induces nonnecroptotic programmed cell death in trophoblasts via IFI16.J Infect Dis.2014 Nov 1;210(9):1476-86

15.Li SN#,Wang W#,Fu SP#,Wang JF#,Liu HM,Xie SS,Liu BR,Li Y,Lv QK,Li ZQ,Xue WJ,Huang BX,Chen W*,Liu JX*. IL-21 modulates release of proinflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways.Mediators Inflamm.2013;2013:548073

著作教材

参译、参编:

1.禽类生理学(第6版)/张才乔,杨焕民主译.-北京:中国农业出版社,2021.12

2.动物生理学实验指导/栾新红主编.-北京:高等教育出版社,2012.4

3.动物生理学/柳巨雄,杨焕民主编.-北京:高等教育出版社,2011.7

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