预防兽医学系

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  • 杜崇涛副教授
  • 性别:男
  • 职称:副教授
  • 硕导/博导:博导
  • 学科专业:预防兽医学
  • 最高学位:博士
  • 研究方向:兽医微生物学与免疫学
  • 最高学历:研究生
  • 邮箱:duct@jlu.edu.cn

讲授课程

本科生:兽医免疫学、动物免疫学、免疫学、兽医微生物与免疫学、疫苗工程学和细胞工程。

硕士研究生:动物免疫学

博士研究生:动物分子免疫学、动物免疫学进展和生物安全与资源等课程

教育经历

1999年6月中国人民解放军军需大学,动物医学,本科

2008年5月威廉希尔williamhill,分子细菌学,硕士学位

2018年6月威廉希尔williamhill,病原微生物与分子免疫学,博士学位

 

工作经历

2004.08-2008.09威廉希尔williamhill畜牧兽医学院助教

2008.10-2018.09william威廉亚洲讲师

2018.10-至今william威廉亚洲副教授

 

科研项目

1.国家自然科学基金:布鲁菌非编码小RNA及其跨物种调控研究(31201908),24.00万元,负责人,2013.01-2015.12;

2.吉林省自然科学基金:miR-21调控肠道菌群的作用机制(20210101002JC),14.00万元,负责人,2021.07-2024.06;

3.企业重点研发课题:新型微生态制剂的研发(3R119M586201),15.00万元,负责人,2019.11-2022.11;

4.威廉希尔williamhill2021年度“学科交叉融合创新”指南类项目:肿瘤内菌群特性及其调控肿瘤发生发展的机制研究(JLUXKJC2021ZY09),10.00万元,负责人,2022.01-2023.12;

5.国家重点研发计划:生物肽、防御素、细菌素等生物治疗制剂研制(2017YFD0501005),147.80万元,参与人,2017.07-2021.06

6.乳脂肪与乳蛋白合成的代谢网络整合与调控,2011CB100800,国家科技部973计划子课题,100.00万元,参与人,2011-2015

7.国家自然科学基金:沙门氏菌感染过程中AIM2的免疫调控作用及其机制研究(31372410),80.00万元,主要参与人,2014.01-2017.12;

8.吉林省省科技厅基础处:P204信号与金葡菌相互调控的分子机制研究(20160101232JC),10.00万元,主要参与人,2016.01-2018.12;

 

学术论文

1.Chong-Tao Du, Wei Gao, Ke Ma, Shui-Xing Yu, Na Li, Shi-Qing Yan, Feng-Hua Zhou, Zhen-Zhen Liu,Wei Chen, Lian-Cheng Lei, Yong-Jun Yang, Wen-Yu Han. MicroRNA146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota. Int J Mol Sci. 2018 Mar 26;19(4)

2.Du C, Feng Y, Wang G, Zhang Z, Hu H, Yu Y, Liu J, Qiu L, Liu H, Guo Z, Huang J, Qiu J. Co-Occurrence of the mcr-1.1 and mcr-3.7 Genes in a Multidrug-Resistant Escherichia coli Isolate from China. Infection and Drug Resistance. 2020 Oct 19; 13: 3649-3655

3.Qinghe Han, Haiyu Wang, Chong Xiao, Ben-Dong Fu,Chong-Tao Du*. Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells. Nat Prod Res. 2017 Jun;31(11):1339-1342

4.Wang G, Liu H, Feng Y, Zhang Z, Hu H, Liu J, Qiu L, Guo Z, Huang J, Qiu J,Du C*. Colistin-resistance mcr genes in Klebsiella pneumoniae from companion animals. J Glob Antimicrob Resist. 2021 Mar 1;25:35-36. doi: 10.1016/j.jgar.2021.02.023. Epub ahead of print. PMID: 33662641.

5.Shui-Xing Yu*,Chong-Tao Du*, Wei Chen, Qian-Qian Lei, Ning Li, Shuai Qi, Xiao-Jing Zhang, Gui-Qiu Hu, Xu-Ming Deng, Wen-Yu Han, Yong-Jun Yang. Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.Sci Rep. 2015 Dec 11;5:17935

6.Liu Z, Wang J, Zhang Y, Wu D, Li S, Jiang A,Du C*, Xie G*. Pterostilbene Exerts Hepatoprotective Effects through Ameliorating LPS/D-Gal-Induced Acute Liver Injury in Mice. Inflammation. 2020 Oct 2

7.Liu J, Zhang Z, Feng Y, Hu H, Yu Y, Qiu L, Liu H, Guo Z, Huang J,Du C*, Qiu J*. Molecular Detection of the mcr Genes by Multiplex PCR. Infection and Drug Resistance. 2020 Oct 12; 13: 3463-3468

8.Gui-Qiu Hu, Yong-Jun Yang, Xiao-Xia Qin, Shuai Qi, Jie Zhang, Shui-Xing Yu,Chong-Tao Duand Wei Chen. Salmonella Outer Protein B Suppresses Colitis Development via Protecting Cell From Necroptosis. Front Cell Infect Microbiol. 2019 Apr 9; 9:87.

9.Zhang J, Qin D, Yang YJ, Hu GQ, Qin XX,Du CT, Chen W. MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota. Mol Immunol. 2019 Mar;107:132-141.

10.Yu SX, Chen W, Hu XZ, Feng SY, Li KY, Qi S, Lei QQ, Hu GQ, Li N, Zhou FH, Ma CY,Du CT, Yang YJ. Liver X receptors agonists suppress NLRP3 inflammasome activation. Cytokine. 2017 Mar;91:30-37.

11.Li N, Fu Y, Chen W, Hu GQ, Zhou M, Yu SX, Zhang XJ,Du CT, Yang YJ. IFI16 mediates soluble Flt-1 and endoglin production by trophoblast cells. J Hypertens. 2015 Aug;33(8):1658-65.

12.Mei Yang,Chongtao Du, Pengjuan Gong, Feifei Xia, Changjiang Sun, Xin Feng, Liancheng Lei, Jun Song, Lei Zhang, Bin Wang, Feng Xiao, Xinwu Yan, Ziyin Cui, Xinwei Li, Jingmin Gu, Wenyu Han . Therapeutic effect of the YH6 phage in a murine hemorrhagic pneumonia model. Res Microbiol. 2015 Oct; 166(8):633-43.

13.Yu SX, Chen W, Liu ZZ, Zhou FH, Yan SQ, Hu GQ, Qin XX, Zhang J, Ma K,Du CT, Gu JM, Deng XM, Han WY, Yang YJ. Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation. Front Immunol. 2018 Feb 2;9:119.

14.Yu SX, Zhou FH, Chen W, Jiang GM,Du CT, Hu GQ, Liu ZZ, Yan SQ, Gu JM, Deng XM, Lin TJ, Duan EK, Yang YJ. Decidual Stromal Cell Necroptosis Contributes to Polyinosinic-Polycytidylic Acid-Triggered Abnormal Murine Pregnancy. Front Immunol. 2017 Aug 2;8:916.

15.Sheng X, You Q, Zhu H, Chang Z, Li Q, Wang H,Wang C, Wang H, Hui L,Du C, Xie X, Zeng R, Lin A, Shi D, Ruan K, Yan J, Gao GF, Shao F, Hu R. Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLoS Pathog. 2017 Jul 28;13(7):e1006534

16.Hu GQ, Song PX, Li N, Chen W, Lei QQ, Yu SX, Zhang XJ,Du CT, Deng XM, Han WY, Yang YJ. AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection. Mucosal Immunol. 2016 Sep; 9(5):1330-9

17.Chu X, Chen W, Li N, Hu XZ,Du CT, Yu SX, Zhou M, Zhang XJ, Jiang GM, Han WY, Deng XM, Yang YJ. Cytosolic double-stranded DNA induces nonnecroptotic programmed cell death in trophoblasts via IFI16. J Infect Dis. 2014 Nov 1;210(9):1476-86

18.Gu J, Feng Y, Feng X, Sun C, Lei L, Ding W, Niu F, Jiao L, Yang M, Li Y, Liu X, Song J, Cui Z, Han D,Du C, Yang Y, Ouyang S, Liu ZJ, Han W. Structural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysin. PLoS Pathog. 2014 May 15;10(5):e1004109

19.Liu Q, Han W, Sun C, Zhou L, Ma L, Lei L, Yan S, Liu S,Du C, Feng X. Deep sequencing-based expression transcriptional profiling changes during Brucella infection. Microb Pathog. 2012 May;52(5):267-77

20.Xie F, Lei L,Du C, Li S, Han W, Ren Z. Genomic differences between Actinobacillus pleuropneumoniae serotypes 1 and 3 and the diversity distribution among 15 serotypes. FEMS Microbiol Lett. 2010 Feb;303(2):147-55.

21.杜崇涛,张晓静,杨梅,刘宏涛,冯世源,韩文瑜.非编码RNA在胞内病原菌免疫逃逸与致病中的作用[J].生命科学,2014,26(09):897-902.(国家自然基金“双清论坛”邀请综述)

代表性专利

1.雷连成,杜崇涛, et al.一种合成三聚氰胺完全抗原的方法及检测三聚氰胺的ELISA试剂盒,ZL200810051488.5

2.雷连成,杜崇涛, et al.利用抗菌肽制备细菌菌影的方法及应用,ZL200910067286.4

3.雷连成,杜崇涛, et al.联合利用抗菌肽和超高压制备细菌菌影的方法及应用,ZL200910067287.9

 

著作教材

1.《高级动物免疫学》,科学出版社,2016,参编

2.《野生动物疫病学》,高等教育出版社,2011,参编

3.《动物疾病病理诊断学》,科学出版社,2010,参编

 

获奖情况

1. 4种重要人兽共患病原细菌耐药机制及耐药性抑制剂的研究(2009J10016),吉林省科技进步一等奖,2009

2.几种新型抗菌肽的发现、基因工程制备及活性机制研究(2012J10004),吉林省科技进步一等奖,2012

3.动物布氏杆菌病、结核病新型快速诊断与检疫技术的创制,吉林省科技进步三等奖,2016

4.担任指导教师获得全国老员工生命科学竞赛(2021,创新创业类)一等奖

5.担任指导教师获得2021年威廉希尔williamhill老员工生命科学创新创业大赛竞赛一等奖

6.担任指导教师获得威廉希尔williamhill2021年“挑战杯”老员工课外学术科技作品竞赛一等奖

7.担任本科班主任所带班级荣获2009年威廉希尔williamhill“十佳班级”、“威廉希尔williamhill农学部学部贡献三等奖”等

 

社会兼职

国家农业农村部学科群重点实验室学术委员会专家

 

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