科研项目: |
(1)国家自然科学基金委员会,青年科学基金项目,转录因子EB调控高NEFA血症奶牛肝脂沉积的机制研究, 2021-01-01至2023-12-31,主持 (2)吉林省教育厅,吉林省教育厅科学研究项目,高浓度NEFA损伤自噬引发脂肪肝奶牛肝脂沉积的机制研究, 2022-01至2023-12, 2.5万元,主持 (3)吉林省科技厅,吉林省优秀青年人才专项, PINK1/Parkin介导的线粒体自噬在高酮血症奶牛肝脏氧化损伤中的作用机制, 2021-01至2022-12,主持 (4)中国博士后科学基金会,第66批中国博士后科学基金面上资助, TFEB和PGC-1α协同调节酮病奶牛肝脏线粒体稳态的机制, 2019-11至2021-07,主持 (5)中国博士后科学基金会,第1批中国博士后科学基金特别资助(站前), PPARα介导的自噬调控围产期奶牛脂肪肝发生发展的机制研究, 2019-07至2021-07,主持 |
代表性学术论文: |
(1)Xiliang Du#, Chiara Di Malta#, Zhiyuan Fang, Taiyu Shen, Xiaodi Niu, Meng Chen, Bo Jin, Hao Yu, Lin Lei, Wenwen Gao, Yuxiang Song, Zhe Wang, Chuang Xu, Zhijun Cao, Guowen Liu*, Xinwei Li*. Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway. Acta Pharmaceutica Sinica B. 2022.IF: 11.614,中科院一区 (2) Xinwei Li, Zhen Shi, Yiwei Zhu, Taiyu Shen, Heyuan Wang, Guanghou Shui, Juan J. Loor, Zhiyuan Fang, Meng Chen, Xinghui Wang, Zhicheng Peng, Yuxiang Song, Zhe Wang,Xiliang Du*, Guowen Liu*. Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol. 2020 Aug;177(15):3591-3607.IF: 8.739,中科院一区 (3)Xiliang Du#, Yiwei Zhu, Zhicheng Peng, Yuanxu Cui, Qiang Zhang, Zhen Shi, Yuan Guan, Xueying Sha, Taiyu Shen, Yuchen Yang, Xiaobing Li, Zhe Wang, Xinwei Li*, Guowen Liu*. High concentrations of fatty acids and β-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows. Journal of Dairy Science, 2018, 101(4):3476-3487.封面文章, IF: 4.034,中科院一区 (4) Wenwen Gao, Zhiyuan Fang, Lin Lei, Lingxue Ju, Bo Jin, Juan J Loor, Yusheng Liang, Zhen Shi, Taiyu Shen , Hao Yu, Meng Chen, Hongsheng Ouyang, Yuxiang Song, Zhe Wang, Guowen Liu, Xinwei Li,Xiliang Du*. Propionate alleviates palmitic acid-induced endoplasmic reticulum stress by enhancing autophagy in calf hepatic cells. J Dairy Sci. 2021 Aug;104(8):9316-9326.IF: 4.034,中科院一区 (5) Zhiyuan Fang#, Xinwei Li#, Shu Wang, Qianming Jiang, Juan J Loor, Xiuhuan Jiang, Lingxue Ju, Hao Yu, Taiyu Shen, Men Chen, Yuxiang Song, Zhe Wang,Xiliang Du*, Guowen Liu*. Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis. J Dairy Sci. 2022 May;105(5):4520-4533.IF: 4.034,中科院一区 |