性别：

女

职称：

教授

硕导/博导：

博导

最高学位：

博士

最高学历：

研究生

办公电话：

0431-87836718

邮箱：

li_yuanyuan@jlu.edu.cn

详细情况

学科专业：

兽医公共卫生

研究方向：

新型纳米探针的设计及在疾病可视化方面的应用；救治药物研发；新型纳米疫苗及佐剂的开发

讲授课程：

科技论文写作；生物安全

教育经历：

2007.9-2011.7 东北林业大学 动物医学 本科

2011.9-2014.7 中国农业科学院哈尔滨兽医研究所 预防兽医学 硕士

2014.9-2017.12 中国科学经理春应用化学研究所 分析化学 博士

工作经历：

2017.12-2020.12 香港科技大学 博士后

2021.1-至今，威廉希尔williamhill william威廉亚洲 教授

简介

威廉希尔williamhill唐敖庆领军教授，国家高层次人才基金获得者，吉林省长白山特聘青年拔尖人才。

主持国家自然科学基金，吉林省科技发展计划 "重点研发 "， 十四五国家重点研发计划 "生物安全关键技术研究 "子课题等多项基金。主要从事人兽共患病综合防控技术方面的研究，包括新型救治药物研发、免疫佐剂的合成及评价、疾病致病机制的可视化研究。 以第一作者或通讯作者在国际著名学术期刊杂志上共发表学术论文 近30篇 ，包括Nature Communications等影响因子大于10的22篇，累计影响因子超过400。

科研项目：

1. 国家自然科学基金优秀青年科学基金项目（海外），200万元，主持。

2. 威廉希尔williamhill高层次人才启动基金，200万，主持。

3. 吉林省科技发展计划项目（重点研发），狂犬病复制缺陷基因工程疫苗的研制，50万，主持。

4. 国家自然科学基金青年基金项目1项，聚集诱导发光材料用于狂犬病病毒入侵宿主细胞动态示踪研究， 30.00万元，主持。

5. 国家重点研发计划项目“生物安全关键技术研究”子课题1项，人畜共患病烈性传染病临床救治创新技术与防护规范研究（2021YFC2600200），60万，项目骨干。

6. 深圳学科布局项目“聚集诱导发光（AIE）材料在生物成像与诊疗一体化中的应用研究”，200 万，参与，结题。

7. 深圳自由探索项目“多组分聚合制备非传统发光聚合物及其生物应用”，50万，参与，在研。

学术论文：

近5年发表学术论文（按时间顺序）

1. Zhe Feng, Yuanyuan Li+, Siyi Chen, Jin Li, Tianxiang Wu, Yanyun Ying, Junyan Zheng, Yuhuang Zhang, Jianquan Zhang, Xiaoxiao Fan, Xiaoming Yu, Dan Zhang, Ben Zhong Tan*, Jun Qian*, Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification. Nat. Commun. (2023), 14 (1), 5017. (Co-first author, IF=11.88)

2. Wentao Wang, Yumeng Gao, Ming Zhang*, Yuanyuan Li*, and Ben Zhong Tang*, Neutrophil-like Biomimic AIE Nanoparticles with High-Efficiency Inflammatory Cytokine Targeting Enable Precise Photothermal Therapy and Alleviation of Inflammation. ACS Nano (2023), 17 (8), 7394-7405. (IF=14.58, Corresponding author)

3. Yujie Bai, Eric Y. Yu, Yongsai Liu, Hongli Jin, Xingqi Liu, Xiaoyu Wu, Mengyao Zhang, Na Feng, Pei Huang, Haili Zhang, Ryan. T. K. Kwok, Xianzhu Xia, Yuanyuan Li*, Ben Zhong Tang*, Hualei Wang*, Molecular Engineering of AIE Photosensitizers for Inactivation of Rabies Virus. Small (2023), 2303542. (IF=13.8, Corresponding author)

4. Mengyao Zhang, Hongli Jin, Yuanyuan Li*,Cuicui Jiao, Pei, Huang, Yujie Bai, Zhiyuan Gong, Haili Zhang, Shunjie Liu, Hualei Wang*, Genetically engineered bacterial-like particles induced specific cellular and humoral immunity as effective tick-borne encephalitis virus vaccine. Aggregate (2023), 4, e305. (IF=17.52, Corresponding author)

5. Wentao Wang, Fan Wu, Mohsen Mohammadniaei, Ming Zhang,*, Yuanyuan Li,* Yi Sun,* Ben Zhong Tang, * Genetically edited T-cell membrane coated AIEgen nanoparticles effectively prevents glioblastoma recurrence, Biomaterials 293 (2023) 121981. (IF=15.304, Corresponding author)

6. Wentao Wang, Yumeng Gao, Ming Zhang*, Yuanyuan Li*, and Ben Zhong Tang* Neutrophil-like Biomimic AIE Nanoparticles with High-Efficiency Inflammatory Cytokine Targeting Enable Precise Photothermal Therapy and Alleviation of Inflammation, ACS Nano (2023) 8, 7394–7405. (IF=14.58, Corresponding author)

7. Yujie Bai, Pei Huang, Na Feng, Yuanyuan Li*, Jingbo Huang, Hongli Jin, Mengyao Zhang, Jingxuan Sun, Nan Li, Haili Zhang, Xianzhu Xia, Ben Zhong Tang*, Hualei Wang*, Treat the “Untreatable” by a Photothermal Agent: Triggering Heat and Immunological Responses for Rabies Virus Inactivation, Adv. Sci. (2022) 2205461. (IF=17.52, Corresponding author)

8. Jingxuan Sun, Yujie Bai, Eric Y. Yu, Guanyu Ding, Haili Zhang, Ming Duan, Pei Huang, Mengyao Zhang, Hongli Jin, Ryan T. K. Kwok, Yuanyuan Li*, Guo Gang Shan*, Ben Zhong Tang*, Hualei Wang*, Self-cleaning wearable masks for respiratory infectious pathogen inactivation by type I and type II AIE photosensitizer, Biomaterials (2022) 121898. (IF=15.304, Corresponding author)

9. Guanyu Ding, Jialin Tong, Yingchen Duan, Shuang Wang, Zhongmin Su, Kuizhan Shao, Lingyu Zhang, Daoming Zhu, Li Li Wen, Yuanyuan Li*, Guo Gang Shan*, Boosting the photodynamic therapy of near-infrared AIE-active photosensitizers by precise manipulation of the molecular structure and aggregate-state packing, Journal of Materials Chemistry B  (2022) ,10(30) 5818-5825. (IF=7.571, Corresponding author)

10. Wentao Wang, Fan Wu, Qicheng Zhang, Ninglin Zhou, Ming Zhang*, Tao Zheng*, Yuanyuan Li*, and Ben Zhong Tang* Aggregation-Induced Emission Nanoparticles for Single Near-Infrared Light-Triggered Photodynamic and Photothermal Antibacterial Therapy. ACS Nano, (2022) ,16, 5, 7961–7970. (IF=14.58, Corresponding author)

11. Yuanyuan Li*, Xiaoxiao Fan, Yirun Li, Shunjie Liu, Clarence Chuah, Youhong Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Xuefeng Lu*, Jun Qian*, and Ben Zhong Tang* Molecular Crystal Engineering of Organic Chromophores for NIR-II Fluorescence Quantification of Cerebrovascular Function. ACS Nano, (2021), 16, 3323-3331. (IF=14.58)

12. Yirun Li+, Xiaoxiao Fan+, Yuanyuan Li+, Liang Zhu, Runze Chen, Yiyin Zhang, Huwei Ni, Qiming Xia, Zhe Feng, Ben Zhong Tang*, Jun Qian*, Hui Lin*, Biologically excretable AIE nanoparticles wear tumor cell-derived “exosome caps” for efficient NIR-II fluorescence imaging-guided photothermal therapy. Nano Today, (2021), 41, 101333. (IF=20.75, co-first author)

13. Eric Y. Yu,  Michelle M. S. Lee,  Joe H. C. Chau,  Kristy W. K. Lam,  Hojeong Park, Ryan T. K. Kwok,*   Jacky W. Y. Lam,   Yuanyuan Li* and  Ben Zhong Tang *,  One-step light-up metabolic probes for in situ discrimination and killing of intracellular bacteria. Mater. Chem. Front., 2022, 6, 450-458. (2022). (IF=6.78, Corresponding author)

14. Yuanyuan Li+*, Jianquan Zhang+, Shunjie Liu, Chen Zhang, Clarence Chuah, Youhong Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Hanlin Ou*, Dan Ding, Ben Zhong Tang*, Enlarging Reservoir: High Absorption Coefficient Dyes Enable Synergetic Near Infrared-II Fluorescence Imaging and Near Infrared-I Photothermal Therapy. Adv. Funct. Mater. 2021, 2102213. (IF=14.86).

15. Yuanyuan Li+, Zhaochong Cai+, Shunjie Liu+, Haoke Zhang, Sherman T. H. Wong, Jacky W. Y. Lam, Ryan T. K. Kwok, Jun Qian*, and Ben Zhong Tang*, Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels, Nat. Commun., (2020), 11, 1255.  (IF=11.88)

16. Yuanyuan Li+, Shunjie Liu+, Huwei Ni+, Haoke Zhang, Hequn Zhang, Clarence Chuah, Chao Ma, Kam Sing Wong, Jacky W. Y. Lam, Ryan T. K. Kwok, Jun Qian*, Xuefeng Lu*, Ben Zhong Tang*, ACQ‐to‐AIE Transformation: Tuning Molecular Packing by Regioisomerization for Two‐photon NIR Bioimaging, Angew. Chem. Int. Ed., (2020), 59, 12822. (IF=12.25)

17. Yuanyuan Li+, Chuansheng Li+, Tao Jiang+, Lihua Zhou, Pengfei Zhang, Ryan T. K. Kwok, Jacky Wing Yip Lam, Ping Gong, Lintao Cai, and Ben Zhong Tang, Aptamer-Anchored Rubrene-Loaded Organic Nanoprobes for Cancer Cell Targeting and Imaging, CCS Chemistry, (2019), 1(3): 251-260. (IF=13.17)

18. Hongbo Cheng+, Yuanyuan Li+, et al., Assembly strategies of organic-based imaging agents for fluorescence and photoacoustic bioimaging applications. Chem. Soc. Rev., (2020). 49, 21-31. (co-first author) (IF=41.35)

19. Tianfu Zhang+, Yuanyuan Li+, Zheng Zheng, Ruquan Ye, Yiru Zhang, Ryan T. K. Kwok, Jacky W. Y. Lam, and Ben Zhong Tang, In-situ Monitoring Apoptosis Process by a Self-reporting Photosensitizer, J. Am. Chem. Soc., (2019), 141, 5612-5616. (co-first author) (IF=14.75)

20. Hai-Tao Feng+*, Yuanyuan Li+, Xingchen Duan, Xiaoxuan Wang, Chunxuan Qi, Jacky W. Y. Lam, Dan Ding, and Ben Zhong Tang, Substitution Activated Precise Phototheranostics through Supramolecular Assembly of AIEgen and Calixarene, J. Am. Chem. Soc., (2020), 142, 37, 15966–15974. (co-first author) (IF=14.75)

21. Yuanyuan li+, Shunjie Liu+, Ryan T. K. Kwok, Jacky W. Y. Lam, and Ben Zhong Tang. Sparks fly when AIE meets with polymers. Mater. Chem. Front., 2019, 3, 2207-2220. (IF=6.78)

22. Shunjie Liu+, Haoke Zhang+, Yuanyuan Li+, Junkai Liu, Lili Du, Ming Chen, Ryan T. K. Kwok, Jacky W. Y. Lam, David Lee Phillips, and Ben Zhong Tang, Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect. Angew. Chem. Int. Ed., (2018), 46, 15409-15413. (co-first author) (If=12.25)

23. Shunjie Liu+, Yuanyuan Li+, et al. Molecular Motion in the Solid State. ACS Mater. Lett., (2019), 1, 425-431. (co-first author)

24. Pengfei Zhang+, Tao Jiang+, Yuanyuan Li+, Zheng Zhao, Ping Gong, Lintao Cai, Ryan T. K. Kwok, Jacky Wing Yip Lam, Xinggui Gu, and Ben Zhong Tang. Zhang P, Jiang T, Li Y, et al. Bio‐orthogonal AIE Dots Based on Polyyne-Bridged Red-emissive AIEgen for Tumor Metabolic Labeling and Targeted Imaging. Chem Asian J., (2019), 14, 770-774. (co-first author) (IF=3.55)

著作教材：

获奖情况：

2021年吉林省“长白山特聘青年拔尖人才”

获宝鸡市自然科学优秀学术成果一等奖

青年教师教学比赛，二等奖，william威廉亚洲

社会兼职：

中国预防兽医学学会犬学分会理事

吉林省预防医学会常务委员

长春畜牧业专家库成员