性别：

女

职称：

教授

硕导/博导：

博导

最高学位：

博士

最高学历：

研究生

办公电话：

0431-87836716

邮箱：

hupan84@163.com

详细情况

学科专业：

兽医公共卫生

研究方向：

兽医公共卫生学，人兽共患细菌病，动物性食品安全，肿瘤微生物组学

讲授课程：

本科生：兽医公共卫生学

硕士生：兽医公共卫生学、食品病原微生物学、食品卫生与安全进展、动物产品与食品安全检验技术

教育经历：

2003.09–2007.06，黑龙江八一农垦大学，动物科技学院，本科

2007.09–2010.06，黑龙江八一农垦大学，动物科技学院，硕士

2010.09–2013.06，威廉希尔williamhill，william威廉亚洲，博士

工作经历：

2013.09–2016.10，威廉希尔williamhill，人兽共患病研究所，讲师

2014.04–2019.12，威廉希尔williamhill，第一医院，博士后

2016.10–2022.12，威廉希尔williamhill，人兽共患病研究所，副教授

2023.01-至今，威廉希尔williamhill，人兽共患病研究所，教授

科研项目：

1.威廉希尔williamhill“学科交叉融合创新”项目，项目编号JLUXKJC2021ZY08，肿瘤内菌群特性及其调控肿瘤发生发展的机制研究，在研，主持人。

2.横向课题：基于菌影技术研制狐貉肺炎病原菌亚单位疫苗，项目编号：3R115J156206，资助年限：2021/07-2024/12，在研，主持人。

3.吉林省科技发展计划重点研发项目：“靶向胃泌素Ⅱ型受体胃癌重组蛋白药的开发与临床前研究”，项目编号20200404123YY，资助年限：2020/01-2022/12，在研，主持人。

4.横向课题：单增李斯特菌胶体金试纸条研制，项目编号：3R119L796206，资助年限：2019/11-2021/06，已结题，主持人。

5.吉林省青年科研基金项目“高效靶向CCK2R重组毒素临床适用结肠癌病例分析” 项目编号20160520162JH，资助年限：2016/01-2018/12，已结题，主持人。

6.国家青年自然基金资助项目：“结肠癌靶向重组毒素rCCK8PE38生物特性研究”，项目编号81401953，资助年限：2015/01-2017/12，已结题，主持人。

7.中央高校基本科研业务费专项资金资助：“基于STX适配子的无毒ELOSA检测方法研究”，项目编号451160306025，资助年限：2016/05-2018/05，已结题，主持人。

学术论文：

发表代表性文章：

1. Qiang Zhao¹, Pan Hu¹, Qianqian Li, Shasha Zhang, Hanxiao Li, Jiang Chang, Qiujie Jiang,Yu Zheng, Yansong Li, Zengshan Liu, Honglin Ren^* and Shiying Lu^*. Prevalence and transmission characteristics of Listeria species from ruminants in farm and slaughtering environments in China[J]. Emerging Microbes & Infections.2021 Dec;10(1):356-364.

2. Ruoran Shi¹, Fazheng Yu¹, Xueyu Hu, Yan Liu, Yuanyuan Jin, Honglin Ren, Shiying Lu, Jian Guo, Jiang Chang, Yansong Li, Zengshan Liu, Xiaoxu Wang^*, and Pan Hu^*. Protective Effect of Lactiplantibacillus plantarum subsp.plantarum SC-5 on Dextran Sulfate Sodium—Induced Colitis in Mice[J]. Foods, 2023, 12, 897.

3. Xun Guo¹, Jiang Chang¹, Shiying Lu¹, Pan Hu¹, Deying Zou, Yansong Li, Feng Li, Jishan Liu, Qi Cao, Kai Zhang, Junpeng Zhan, Yixin Liu, Xin Yang, Honglin Ren^*. Multiantigen epitope fusion recombinant proteins from capsids of serotype 4 fowl adenovirus induce chicken immunity against avian Angara disease[J]. Veterinary Microbiology, 2023, 109661.

4. Jiang Chang¹, Deying Zou¹, Honglin Ren¹, Xilin Liu, Meng Li, Zhaozhao Si, Cheng Han, Zengshan Liu, Shiying Lu, Pan Hu^*. An ultrasensitive and long-lasting chemiluminescence immunoassay for IP-10 detection based on a 4-bromophenol-reinforced bienzymatic system[J]. Microchemical Journal, 2022, 107719.

5. Jiang Chang¹, Xilin Liu¹, Honglin Ren¹, Shiying Lu¹, Meng Li, Song Zhang, Ke Zhao, Hanxiao Li, Xiaoshi Zhou, Lixiong Peng, Zengshan Liu, and Pan Hu^*. Pseudomonas Exotoxin A-Based Immunotherapy Targeting CCK2R Expressing Colorectal Malignancies：An In Vitro and In Vivo Evaluation[J]. Molecular Pharmaceutics, 2021, 18(6): 2285-2297.

6. Bin Qiao¹, Yansong Li¹, Pan Hu¹, Yu Sun, Zhaozhao Si, Shiying Lu, Honglin Ren, Zengshan Liu, Ying Zhang, Lei Meng, Yu Zhou^*, EuNPs-MAb fluorescent probe based immunochromatographic strip for rapid and sensitive detection of fluorene, Sensors and Actuators B: Chemical, 2018, 262: 221-227.

7. Hu P¹, Zhang S¹, Lu SY, Li M, Chang J, Wang MY, Li C, Zhao K, Guan YT, Zhang YY, Li YS, Zhou Y, Liu ZS, Bai O, Ren HL.An efficient scheme for purification of a novel recombinant immunotoxin, rCCK8PE38, for anti-tumour experiments.Biomed Chromatogr. 2018, 32(6):e4197.

8. YuZheng¹, PanHu¹, HonglinRen¹, HanWang, QiCao, QiangZhao, HanxiaoLi, HailingZhang, ZhanxuLiu, YansongLi, CongWang, ZengshanLiu, ShiyingLu^*. RPA-SYBR Green I based instrument-free visual detection for pathogenic Yersinia enterocolitica in meat[J]. Analytical Biochemistry, 2021, 621, 114157.

9. Han Wang¹, Hong‑Lin Ren¹, Pan Hu¹ , Yan‑Song Li, Yu Zheng, Qi Cao, Zhan‑Xu Liu, Zeng‑Shan Liu, Yong Yang, Shi‑Ying Lu^*, A Fluorescence Immunochromatographic Strip Based on Quantum Dot Nanobeads for the Rapid Detection of Okadaic Acid[J], Food Analytical Methods, 2022 April 25 , https://doi.org/10.1007/s12161-022-02302-6.

10. Li M¹, Chang J¹, Ren H¹, Song D, Guo J, Peng L, Zhou X, Zhao K, Lu S, Liu Z, Hu P^*. Downregulation of CCKBR Expression Inhibits the Proliferation of Gastric Cancer Cells, Revealing a Potential Target for Immunotoxin Therapy. Curr Cancer Drug Targets. 2022 Jan 6. doi: 10.2174/1568009622666220106113616.

11. Lixiong Peng¹, Jiang Chang¹, Xilin Liu¹, Shiying Lu¹, Honglin Ren, Meng Li, Xiaoshi Zhou, Ke Zhao, Jian Guo, Hanxiao Li, Zengshan Liu, and Pan Hu^*. MC1R is a prognostic marker and its expression is correlated with MSI in colorectal cancer[J],  Current Issues in Molecular Biology,  2021 Oct 11;43(3):1529-1547.

12. Han Wang¹, Zong-Cheng Wu¹, Pan Hu¹, Hong Lin Ren¹, Yan Song Li, Yu Zheng, Cong Wang, Zeng-Shan Liu, Shi-Ying Lu^*. Identification of chicken-derived scFv against N-glycolylneuraminic acid retrieved from an immune library by phage display[J]. Protein Expression and Purification.2021 Feb.

13. Hong Zhang¹, Shiying Lu¹, Honglin Ren, Ke Zhao, Yansong Li, Yuting Guan, Hanxiao Li, Yu Zheng, Pan Hu^* and Zengshan Liu^*. Acute oral toxicity and acute intraperitoneal studies of thermally treated ceftiofur[J]. Chemical and Pharmaceutical Bulletin. 2020 SEP, 68, 1061–1068.

14. Jiang Chang¹, ZengShan Liu¹, De Feng Song¹, Meng Li, Song Zhang,Ke Zhao, Yu Ting Guan, Hong Lin Ren, Yan Song Li, Yu Zhou, Xi Lin Liu^* , Shi Ying Lu^* and Pan Hu^* . Cholecystokinin type 2 receptor in Colorectal cancer: Diagnostic and Therapeutic Target[J]. Journal of cancer research and clinical oncology. 2020 Sep, 146(9):2205-2217.

15. Shi-Jun Zhang¹, Xing Guo¹, Pan Hu¹, Shi-Ying Lu¹, Nan-Nan Liu, Bao-Quan Fu, Nan Wang, Yan-Song Li, Lu-Lu Wang, Jiang Chang, Heng-Zhen Chang, Zeng-Shan Liu, Yu Zhou, Hong-Lin Ren^*. Characterization of a Novel Interleukin-1 Receptor Antagonist From Sheep ( Ovis aries) [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 2020 May, 40(5): 268-278.

16. Hong Zhang¹, Shiying Lu¹, Honglin Ren, Ke Zhao, Yansong Li, Yuting Guan, Hanxiao Li, Pan Hu^* and Zengshan Liu^*. Cytotoxicity and degradation product identification of thermally treated ceftiofur [J]. RSC Advances, 2020 May, 10, 18407-18417.

17. Song YX¹, Hu P¹, Bai YL, Zhao C, Xia C^*, Xu C. Plasma Metabolic Characterisation of Dairy Cows with Inactive Ovaries and Oestrus During the Peak of Lactation[J]. J Vet Res. 2019 Sep 13, 63(3): 359-367.

18. Wang LL¹, Chen XF¹, Hu P¹, Lu SY¹, Fu BQ, Li YS, Zhai FF, Ju DD, Zhang SJ, Shui YM, Chang J, Ma XL, Su B, Zhou Y, Liu ZS, Ren HL^*. Host Prdx6 contributing to the intracellular survival of Brucella suis S2 strain[J]. BMC Vet Res. 2019 Aug 22, 15(1): 304.

著作教材：

1. 柳增善; 任洪林; 孙洪斌; 刘明远; 吴广智; 胡盼; 柳溪林; 孟宪荣; 黄金林; 白雪; 卢士英; 李岩松; 张英, 食品病原微生物学（十二五规划教材), 科学出版社, 2015,（副主编）

2. 柳增善; 任洪林; 崔树森; 李春雨; 孙洪斌;卢士英; 胡盼;李岩松; 孟宪梅;于师宇; 吴秀平; 王洋; 杨咏洁; 王文悦, 食品病原微生物学, 化学工业出版社, 2015,（副主编）

3.柳增善; 卢士英; 崔树森; 李春雨; 柳溪林; 胡盼; 吴广智; 任洪林; 刘明远; 佟伟华, 人兽共患病学（十二五规划教材), 科学出版社, 2014,（副主编）

4. 柳增善; 任洪林; 张守印; 卢士英; 李岩松; 唐峰; 王颖; 周玉; 柳溪林; 张茂林; 宋杰; 孟宪梅; 于师宇; 郭德军; 胡盼; 动物检疫检验学（十二五规划教材), 科学出版社2012, （参编）

获奖情况：

1.中国商业联合会科学技术进步一等奖；

2.威廉希尔williamhill2021年第二届智慧课堂教学创新大赛三等奖；

3.威廉希尔williamhill2019年课堂教学质量优秀奖；

4.威廉希尔williamhill2019年教学成果三等奖；

5.威廉希尔williamhill2019年优秀共产党员；

6.威廉希尔williamhill2018年“教学育人”先进个人；

7.威廉希尔williamhill2018年第八届“青年教师教学水平大赛”一等奖；

8.威廉希尔williamhill2016年优秀党务工作者。

社会兼职：

人兽共患病学协会理事；中国抗癌协会会员。